Article

CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy

2020-03-23

Abstract excerpt

<title>Abstract</title> <p>Background: Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the CF heart. <h4>Results:</h4> Here, we used a zebrafish model, which lacks lung tissue, to investigate the role of CFTR in cardiogenesis during embryonic...

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Literature Corpus work: a437b650-291f-54f2-bbb0-89de21c5094d
DOI: 10.21203/rs.3.rs-18648/v1

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