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Article

The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice.

Science China. Life sciences - 1 Jul 2018

Chen Yongkun, Bai Tian, Zhu Wenfei, Gao Rongbao, Deng Zhihong, Shi Yi, Zou Shumei, Huang Yiwei, Li Xiyan, Li Fangcai, Feng Zhaomin, Chen Tao, Yang Jing, Wang Dayan, Gao Lidong, Shu Yuelong

Abstract excerpt

Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses...

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PMID: 29445999
DOI: 10.1007/s11427-017-9156-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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