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Article

Glycosylation on hemagglutinin affects the virulence and pathogenicity of pandemic H1N1/2009 influenza A virus in mice.

PloS one - 1 Jan 2013

Zhang Yan, Zhu Jiping, Li Yongtao, Bradley Konrad C, Cao Jiyue, Chen Huanchun, Jin Meilin, Zhou Hongbo

Abstract excerpt

The two glycosylation sites (Asn142 and Asn177) were observed in the HA of most human seasonal influenza A/H1N1 viruses, while none in pandemic H1N1/2009 influenza A (pH1N1) viruses. We investigated the effect of the two glycosylation sites on viral virulence and pathogenicity in mice using recombinant pH1N1. The H1N1/144 and H1N1/177 mutants which gained potential glycosylation sites Asn142 and Asn177 on HA...

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Identifiers

PMID: 23637827
DOI: 10.1371/journal.pone.0061397
PMCID: PMC3634815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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