Validating a breast cancer score in Spanish women. The MCC-Spain study.

doi:10.1038/s41598-018-20832-0

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Validating a breast cancer score in Spanish women. The MCC-Spain study.

Scientific reports - 14 Feb 2018

Dierssen-Sotos Trinidad, Gómez-Acebo Inés, Palazuelos Camilo, Fernández-Navarro Pablo, Altzibar Jone M, González-Donquiles Carmen, Ardanaz Eva, Bustamante Mariona, Alonso-Molero Jessica, Vidal Carmen, Bayo-Calero Juan, Tardón Adonina, Salas Dolores, Marcos-Gragera Rafael, Moreno Víctor, Rodriguez-Cundin Paz, Castaño-Vinyals Gemma, Ederra María, Vilorio-Marqués Laura, Amiano Pilar, Pérez-Gómez Beatriz, Aragonés Nuria, Kogevinas Manolis, Pollán Marina, Llorca Javier

Abstract excerpt

A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping...

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PMID: 29445177
DOI: 10.1038/s41598-018-20832-0
PMCID: PMC5813036

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