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Article

Functional diversification of closely related ARF-GEFs in protein secretion and recycling.

Nature - 26 Jul 2007

Richter Sandra, Geldner Niko, Schrader Jarmo, Wolters Hanno, Stierhof York-Dieter, Rios Gabino, Koncz Csaba, Robinson David G, Jürgens Gerd

Abstract excerpt

Guanine-nucleotide exchange factors on ADP-ribosylation factor GTPases (ARF-GEFs) regulate vesicle formation in time and space by activating ARF substrates on distinct donor membranes. Mammalian GBF1 (ref. 2) and yeast Gea1/2 (ref. 3) ARF-GEFs act at Golgi membranes, regulating COPI-coated vesicle formation. In contrast, their Arabidopsis thaliana homologue GNOM (GN) is required for endosomal recycling, playing...

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Source

Identifiers

PMID: 17653190
DOI: 10.1038/nature05967

Genes

GNL1
GBF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional diversification of closely related ARF-GEFs in protein secretion and recycling.PMID 17653190Read ↗

An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells.Semantic proximity Read ↗

ADP-ribosylation factor machinery mediates endocytosis in plant cells.Semantic proximity Read ↗

Recruitment of Arf1-GDP to Golgi by Glo3p-type ArfGAPs is crucial for golgi maintenance and plant growth.Semantic proximity Read ↗

The integrity of the plant Golgi apparatus depends on cell growth-controlled activity of GNL1.Semantic proximity Read ↗

Coordinated Activation of ARF1 GTPases by ARF-GEF GNOM Dimers Is Essential for Vesicle Trafficking in Arabidopsis.Semantic proximity Read ↗

Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockoutsSemantic proximity Read ↗

The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth.Semantic proximity Read ↗

The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast.Semantic proximity Read ↗

The ARF regulatory GTPase in <i>Giardia intestinalis</i> is associated with vesicle formation and membrane fusion machinery at non-canonical endosomal compartmentsSemantic proximity Read ↗

Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function.Semantic proximity Read ↗

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Semantic proximity Read ↗

The ARF GTPases: defining roles in membrane traffic and organelle structure.Semantic proximity Read ↗

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