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Article

Polymorphism of Gly39Glu (c.116G>A) hMSH6 is associated with sporadic colorectal cancer development in the Polish population: Preliminary results.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Dec 2017

Zelga Piotr, Przybyłowska-Sygut Karolina, Zelga Marta, Dziki Adam, Majsterek Ireneusz

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) remains a major source of cancer-related mortality, accounting for 10% of all cancer-related deaths. DNA mismatch repair mechanism (MMR) responsible for correcting errors generated during DNA replication and its deficiency is associated with both hereditary and sporadic CRC. Single-nucleotide polymorphisms (SNPs) are the most common forms of genetic variation, and it has been...

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PMID: 29442465
DOI: 10.17219/acem/64877

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