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Article

Detection of conformational transformation of antithrombin in blood with crossed immunoelectrophoresis: new application for a classical method.

The Journal of laboratory and clinical medicine - 1 Nov 2003

Corral Javier, Rivera José, Martínez Constantino, González-Conejero Rocio, Miñano Antonia, Vicente Vicente

Abstract excerpt

The structural flexibility of antithrombin is essential for its molecular trapping mechanism but also makes it vulnerable to even minor changes affecting its conformational stability, which influences hemostasis significantly. The conformational transformation of this serpin has been poorly investigated in biologic samples because available immunologic methods hardly differentiate between different conformations...

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Identifiers

PMID: 14647033
DOI: 10.1016/S0022-2143(03)00136-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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