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Chronic neutrophilic leukemia: new science and new diagnostic criteria

13 Feb 2018

Abstract excerpt

Chronic neutrophilic leukemia (CNL) is a distinct myeloproliferative neoplasm defined by persistent, predominantly mature neutrophil proliferation, marrow granulocyte hyperplasia, and frequent splenomegaly. The seminal discovery of oncogenic driver mutations in CSF3R in the majority of patients with CNL in 2013 generated a new scientific framework for this disease as it deepened our understanding of its molecular...

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PMID: 29440636
DOI: 10.1038/s41408-018-0049-8

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