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Chronic neutrophilic leukemia and atypical chronic myeloid leukemia: 2024 update on diagnosis, genetics, risk stratification, and management.

American journal of hematology - 1 Jul 2024

Szuber Natasha, Orazi Attilio, Tefferi Ayalew

Abstract excerpt

Chronic neutrophilic leukemia (CNL) is a rare BCR::ABL1-negative myeloproliferative neoplasm (MPN) defined by persistent mature neutrophilic leukocytosis and bone marrow granulocyte hyperplasia. Atypical chronic myeloid leukemia (aCML) (myelodysplastic "[MDS]/MPN with neutrophilia" per World Health Organization [WHO]) is a MDS/MPN overlap disorder featuring dysplastic neutrophilia and circulating myeloid...

Topics

Humans
Leukemia, Neutrophilic, Chronic
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Mutation
Risk Assessment
Receptors, Colony-Stimulating Factor
Carrier Proteins
Nuclear Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38644693
DOI: 10.1002/ajh.27321

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