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Article

Chronic neutrophilic leukemia: 2020 update on diagnosis, molecular genetics, prognosis, and management.

American journal of hematology - 1 Feb 2020

Szuber Natasha, Elliott Michelle, Tefferi Ayalew

Abstract excerpt

DISEASE OVERVIEW: Chronic neutrophilic leukemia (CNL) is a rare, often aggressive myeloproliferative neoplasm (MPN) defined by persistent mature neutrophilic leukocytosis, bone marrow granulocyte hyperplasia, and frequent hepatosplenomegaly. The seminal discovery of oncogenic driver mutations in colony-stimulating factor 3 receptor (CSF3R) in the majority of patients with CNL in 2013 anchored a new scientific...

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PMID: 31769070
DOI: 10.1002/ajh.25688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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