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An Autocrine Proliferation Repressor Regulates Dictyostelium discoideum Proliferation and Chemorepulsion Using the G Protein-Coupled Receptor GrlH.

mBio - 13 Feb 2018

Tang Yu, Wu Yuantai, Herlihy Sarah E, Brito-Aleman Francisco J, Ting Jose H, Janetopoulos Chris, Gomer Richard H

Abstract excerpt

In eukaryotic microbes, little is known about signals that inhibit the proliferation of the cells that secrete the signal, and little is known about signals (chemorepellents) that cause cells to move away from the source of the signal. Autocrine proliferation repressor protein A (AprA) is a protein secreted by the eukaryotic microbe Dictyostelium discoideum AprA is a chemorepellent for and inhibits the...

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Identifiers

PMID: 29440579
DOI: 10.1128/mBio.02443-17
PMCID: PMC5821085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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