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Article

CbfA, the C-module DNA-binding factor, plays an essential role in the initiation of Dictyostelium discoideum development.

Eukaryotic cell - 1 Oct 2004

Winckler Thomas, Iranfar Negin, Beck Peter, Jennes Ingo, Siol Oliver, Baik Unha, Loomis William F, Dingermann Theodor

Abstract excerpt

We recently isolated from Dictyostelium discoideum cells a DNA-binding protein, CbfA, that interacts in vitro with a regulatory element in retrotransposon TRE5-A. We have generated a mutant strain that expresses CbfA at <5% of the wild-type level to characterize the consequences for D. discoideum cell physiology. We found that the multicellular development program leading to fruiting body formation is highly...

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Identifiers

PMID: 15470262
DOI: 10.1128/EC.3.5.1349-1358.2004
PMCID: PMC522599

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Source receipt: pubmed, retrieved 7 Sept 2026.

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