Article
A putative receptor mediating cell-density sensing in Dictyostelium.
The Journal of biological chemistry - 26 Nov 1999
Deery W J, Gomer R H
Abstract excerpt
When Dictyostelium cells starve, they begin secreting a glycoprotein called conditioned medium factor (CMF). When there is a high density of starved cells, as indicated by a high concentration of CMF, the cells begin expressing some genes and aggregate using pulses of cAMP as a chemoattractant. CMF regulates gene expression via a G protein-independent pathway, whereas CMF regulates cAMP signal transduction via a...
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