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Article

STING-dependent translation inhibition restricts RNA virus replication

12 Feb 2018

Abstract excerpt

In mammalian cells, IFN responses that occur during RNA and DNA virus infections are activated by distinct signaling pathways. The RIG-I-like-receptors (RLRs) bind viral RNA and engage the adaptor MAVS (mitochondrial antiviral signaling) to promote IFN expression, whereas cGAS (cGMP-AMP synthase) binds viral DNA and activates an analogous pathway via the protein STING (stimulator of IFN genes). In this study, we...

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PMID: 29440426
DOI: 10.1073/pnas.1716937115

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