Article
Heritable, Allele-Specific Chromosomal Looping between Tandem Promoters Specifies Promoter Usage of SHC1.
Molecular and cellular biology - 1 May 2018
Li Xichuan, Lin Zhenzhen, Wang Hao, Zhao Dan, Xu Xing, Wei Yiliang, Li Xiaoting, Li Xiaobo, Xiang Yougui, Terada Lance S, Liu Zhe
Abstract excerpt
One-half of the genes in the human genome contain alternative promoters, some of which generate products with opposing functions. Aberrant silencing or activation of such alternative promoters is associated with multiple diseases, including cancer, but little is known regarding the molecular mechanisms that control alternative promoter choice. The SHC1 gene encodes p46Shc/p52Shc and p66Shc, proteins oppositely...
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