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Inherited blood cancer predisposition through altered transcription elongation

12 Jan 2024

Abstract excerpt

Despite advances in defining diverse somatic mutations that cause myeloid malignancies, a significant heritable component for these cancers remains largely unexplained. Here, we perform rare variant association studies in a large population cohort to identify inherited predisposition genes for these blood cancers. CTR9, which encodes a key component of the PAF1 transcription elongation complex, is among the...

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PMID: 38218188
DOI: 10.1016/j.cell.2023.12.016

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