Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

doi:10.1016/j.ccell.2018.01.006

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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Cancer cell - 12 Feb 2018

Booth Christopher A G, Barkas Nikolaos, Neo Wen Hao, Boukarabila Hanane, Soilleux Elizabeth J, Giotopoulos George, Farnoud Noushin, Giustacchini Alice, Ashley Neil, Carrelha Joana, Jamieson Lauren, Atkinson Deborah, Bouriez-Jones Tiphaine, Prinjha Rab K, Milne Thomas A, Teachey David T, Papaemmanuil Elli, Huntly Brian J P, Jacobsen Sten Eirik W, Mead Adam J

Abstract excerpt

Lympho-myeloid restricted early thymic progenitors (ETPs) are postulated to be the cell of origin for ETP leukemias, a therapy-resistant leukemia associated with frequent co-occurrence of EZH2 and RUNX1 inactivating mutations, and constitutively activating signaling pathway mutations. In a mouse model, we demonstrate that Ezh2 and Runx1 inactivation targeted to early lymphoid progenitors causes a marked expansion...

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PMID: 29438697
DOI: 10.1016/j.ccell.2018.01.006

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RUNX1

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