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Article

A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions.

Cancer research - 1 Aug 2000

Fuqua S A, Wiltschke C, Zhang Q X, Borg A, Castles C G, Friedrichs W E, Hopp T, Hilsenbeck S, Mohsin S, O'Connell P, Allred D C

Abstract excerpt

The best current model of breast cancer evolution suggests that most cancers arise from certain premalignant lesions. We have identified a common (34%) somatic mutation in the estrogen receptor (ER)-alpha gene in a series of 59 typical hyperplasias, a type of early premalignant breast lesion. The...

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Source

Identifiers

PMID: 10945602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10945602-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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