Article

miR-519a-3p, found to regulate cellular prion protein during Alzheimer’s disease pathogenesis, as a biomarker of asymptomatic stages

2023-12-15

Abstract excerpt

MiRNAs induce post-transcriptional gene silencing by binding to the 3’-UTR of complementary messenger RNAs and causing either degradation or inhibition of translation. The clinical relevance of miRNAs as biomarkers is growing due to their stability and detection in biofluids. In this sense, diagnosis at asymptomatic stages of Alzheimer’s disease (AD) remains a challenge since it can only be made at autopsy accordi...

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Literature Corpus work: 2e06bb70-46cc-588c-8079-c32e0b2535c6
DOI: 10.1101/2023.12.15.569852

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