Article
Nuclear import of Cdc13 limits chromosomal capping.
Nucleic acids research - 6 Apr 2018
Mersaoui Sofiane Y, Bonnell Erin, Wellinger Raymund J
Abstract excerpt
Cdc13 is an essential protein involved in telomere maintenance and chromosome capping. Individual domain analyses on Cdc13 suggest the presence of four distinct OB-fold domains and one recruitment domain. However, it remained unclear how these sub-domains function in the context of the whole protein in vivo. Here, we use individual single domain deletions to address their roles in telomere capping. We find that...
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