Article
MiR-134, epigenetically silenced in gliomas, could mitigate the malignant phenotype by targeting KRAS.
Carcinogenesis - 8 Mar 2018
Wang Zhi-Liang, Zhang Chuan-Bao, Wang Zheng, Meng Xiang-Qi, Liu Xiao-Juan, Han Bo, Duan Chun-Bin, Cai Jin-Quan, Hao Zhong-Fei, Chen Ming-Hui, Jiang Tao, Li Yong-Li, Jiang Chuan-Lu, Wang Hong-Jun
Abstract excerpt
Gliomas are characterized by a malignant phenotype with proliferation, cell cycle arrest and invasion. To explore the biological consequences of epigenetically regulated miRNAs, we performed a microarray-based screening (whose expression was affected by 5-AZA treatment) followed by bisulfite sequencing validation. We found that miR-134 as an epigenetically regulated suppressor gene with prognostic value in...
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