Article
miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal.
Oncotarget - 10 Nov 2015
Lulli Valentina, Buccarelli Mariachiara, Martini Maurizio, Signore Michele, Biffoni Mauro, Giannetti Stefano, Morgante Liliana, Marziali Giovanna, Ilari Ramona, Pagliuca Alfredo, Larocca Luigi Maria, De Maria Ruggero, Pallini Roberto, Ricci-Vitiani Lucia
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common and fatal malignant adult primary brain tumor. Currently, the overall prognosis for GBM patients remains poor despite advances in neurosurgery and adjuvant treatments. MicroRNAs (miRNAs) contribute to the pathogenesis of various types of tumor, including GBM. In this study we analyzed the expression of a panel of miRNAs, which are known to be differentially...
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