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Article

Role of microRNAs in gliomagenesis: targeting miRNAs in glioblastoma multiforme therapy

19 Jul 2012

Abstract excerpt

INTRODUCTION: Gliomas consist of a very heterogeneous group of malignant tumors, accounting for 50 - 60% of primary brain tumors. Despite all the efforts of cytoreductive surgery in combination with intense chemoradiotherapy, glioblastoma multiforme (GBM, glioma grade IV) still has a dismal prognosis. Current research is focused on molecular targeting to overcome resistance to conventional therapy. MicroRNAs...

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PMID: 22809292
DOI: 10.1517/13543784.2012.710199

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