Article
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2018
Zhou Xiaopu, Chen Yu, Mok Kin Y, Zhao Qianhua, Chen Keliang, Chen Yuewen, Hardy John, Li Yun, Fu Amy K Y, Guo Qihao, Ip Nancy Y
Abstract excerpt
Alzheimer's disease (AD) is a leading cause of mortality among the elderly. We performed a whole-genome sequencing study of AD in the Chinese population. In addition to the variants identified in or around the APOE locus (sentinel variant rs73052335, P = 1.44 × 10-14), two common variants, GCH1 (rs72713460, P = 4.36 × 10-5) and KCNJ15 (rs928771, P = 3.60 × 10-6), were identified and further verified for their...
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