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Article

Effect of GWAS-Identified Genetic Variants on Maximum QT Interval in Patients With Schizophrenia Receiving Antipsychotic Agents: A 24-Hour Holter ECG Study.

Journal of clinical psychopharmacology - 1 Aug 2017

Watanabe Junzo, Fukui Naoki, Suzuki Yutaro, Sugai Takuro, Ono Shin, Tsuneyama Nobuto, Saito Mami, Tajiri Misuzu, Someya Toshiyuki

Abstract excerpt

BACKGROUND: Users of antipsychotics (APs) have a risk of sudden cardiac death (SCD). Sudden cardiac death in such patients is thought to be largely due to drug-induced QT prolongation. It has been reported that many subjects with drug-induced torsades de pointes (TdP) have risk alleles associated with subclinical congenital long QT syndrome. METHODS: We investigated the effects of the risk alleles associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 28590366
DOI: 10.1097/JCP.0000000000000724

Genes

SCD
NDRG4
PLN

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