Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease.

Journal of visualized experiments : JoVE - 28 Nov 2025

Muñoz-Juan Amanda, Laromaine Anna, Yuste Víctor J, Dalfó Esther

Abstract excerpt

Parkinson's disease (PD) is among the most prevalent neurodegenerative disorders and is diagnosed based on motor symptoms that emerge after significant dopaminergic neuron loss. Non-motor symptoms, such as constipation, are the most common and often appear earlier, indicating the onset of the disease. Many animal models are used to study neurodegenerative diseases, yet most focus on the later stages. Because it...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Gastrointestinal Motility

Share to Mutation

Share to Parkinson Disease

Share to rac GTP-Binding Proteins

Share to rac1 GTP-Binding Protein

Source

Identifiers

PMID: 41396855
DOI: 10.3791/69278

Genes

RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease.PMID 41396855Read ↗

Modelling Parkinson's Disease in C. elegans : Strengths and LimitationsSemantic proximity Read ↗

Caenorhabditis elegans as a Model System to Study Human Neurodegenerative DisordersSemantic proximity Read ↗

Traversing a wormhole to combat Parkinson's disease.Semantic proximity Read ↗

A Predictable Worm: Application of Caenorhabditis elegans for Mechanistic Investigation of Movement DisordersSemantic proximity Read ↗

Modeling Parkinson's Disease in C. elegans.Semantic proximity Read ↗

Using a Caenorhabditis elegans Parkinson’s Disease Model to Assess Disease Progression and Therapy EfficiencySemantic proximity Read ↗

Systematic Review of Caenorhabditis elegans Models for Mechanism Research and Drug Discovery in Parkinson’s DiseaseSemantic proximity Read ↗

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.Semantic proximity Read ↗

Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson’s disease, Alzheimer’s disease and autism spectrum disorderSemantic proximity Read ↗

Comparative Analysis of Experimental Methods to Quantify Animal Activity in Caenorhabditis elegans Models of Mitochondrial Disease.Semantic proximity Read ↗

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s DiseaseSemantic proximity Read ↗

Studying the mechanisms of neurodegeneration: C. elegans advantages and opportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.