Article
High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor-/CD52- T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2018
Loeff Floris C, Falkenburg J H Frederik, Hageman Lois, Huisman Wesley, Veld Sabrina A J, van Egmond H M Esther, van de Meent Marian, von dem Borne Peter A, Veelken Hendrik, Halkes Constantijn J M, Jedema Inge
Abstract excerpt
Alemtuzumab (ALM) is used for T cell depletion in the context of allogeneic hematopoietic stem cell transplantation (alloSCT) to prevent acute graft-versus-host disease and graft rejection. Following ALM-based T cell-depleted alloSCT, relatively rapid recovery of circulating T cells has been described, including T cells that lack membrane expression of the GPI-anchored ALM target Ag CD52. We show, in a cohort of...
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