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Article

Expansion of donor-derived hematopoietic stem cells with PIGA mutation associated with late graft failure after allogeneic stem cell transplantation.

Blood - 1 Sept 2008

Mochizuki Kanako, Sugimori Chiharu, Qi Zhirong, Lu Xuzhang, Takami Akiyoshi, Ishiyama Ken, Kondo Yukio, Yamazaki Hirohito, Okumura Hirokazu, Nakao Shinji

Abstract excerpt

A small population of CD55(-)CD59(-) blood cells was detected in a patient who developed donor-type late graft failure after allogeneic stem cell transplantation (SCT) for treatment of aplastic anemia (AA). Chimerism and PIGA gene analyses showed the paroxysmal nocturnal hemoglobinuria (PNH)-type granulocytes to be of a donor-derived stem cell with a thymine insertion in PIGA exon 2. A sensitive mutation-specific...

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Source

Identifiers

PMID: 18596225
DOI: 10.1182/blood-2008-02-141325

Genes

PIGA
SCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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