Article

A reservoir of rituximab-resistant splenic memory B cells contributes to relapses after B-cell depletion therapy

2019-11-07

Abstract excerpt

Immune thrombocytopenia (ITP) is an autoimmune disease mediated by pathogenic antibodies directed against platelet antigens, including GPIIbIIIa. Taking advantage of spleen samples obtained from ITP patients, we characterized by multiples approaches the onset of disease relapses occurring after an initial complete response to rituximab. Analysis of splenic B cell immunoglobulin heavy chain gene repertoire at bulk...

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Literature Corpus work: 29c82b21-ed57-5178-9252-785c81639437
DOI: 10.1101/833343

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