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Article

Are Nonsense Alleles of Drosophila melanogaster Genes under Any Selection?

Genome biology and evolution - 1 Apr 2018

Potapova Nadezhda A, Andrianova Maria A, Bazykin Georgii A, Kondrashov Alexey S

Abstract excerpt

A gene which carries a bona fide loss-of-function mutation effectively becomes a functionless pseudogene, free from selective constraint. However, there is a number of molecular mechanisms that may lead to at least a partial preservation of the function of genes carrying even drastic alleles. We performed a direct measurement of the strength of negative selection acting on nonsense alleles of protein-coding genes...

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Identifiers

PMID: 29425311
DOI: 10.1093/gbe/evy032
PMCID: PMC5888714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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