Article
A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate.
Trends in genetics : TIG - 1 Jul 2005
Wyckoff Gerald J, Malcom Christine M, Vallender Eric J, Lahn Bruce T
Abstract excerpt
Under prevailing theories, the nonsynonymous-to-synonymous substitution ratio (i.e. K(a)/K(s)), which measures the fixation probability of nonsynonymous mutations, is correlated with the strength of selection. In this article, we report that K(a)/K(s) is also strongly correlated with the mutation rate as measured by K(s), and that this correlation appears to have a similar magnitude as the correlation between...
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