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Spotlight on Ferroptosis: Iron-Dependent Cell Death in Alzheimer’s Disease

14 Jul 2020

Abstract excerpt

Alzheimer's disease is an emerging global epidemic that is becoming increasingly unsustainable. Most of the clinical trials have been centered around targeting β-amyloid and have met with limited success. There is a great impetus to identify alternative drug targets. Iron appears to be the common theme prevalent across neurodegenerative diseases. Iron has been shown to promote aggregation and pathogenicity of the...

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PMID: 32760266
DOI: 10.3389/fnagi.2020.00196

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