Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges (Review)

Abstract excerpt

Lynch syndrome (LS) is an autosomal dominant genetic disorder associated with germline mutations in DNA mismatch repair (MMR) genes. The carriers of pathogenic mutations in these genes have an increased risk of developing a colorectal cancer and/or LS-associated cancer. The LS-associated cancer types include carcinomas of the endometrium, small intestine, stomach, pancreas and biliary tract, ovary, brain, upper...

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• Colorectal and Anal Carcinomas
• Colorectal Cancer Screening and Detection
• Genetic factors in colorectal cancer