TNF-α Polymorphisms and Maternal Depression in a Mexican Mestizo Population.

doi:10.2174/1871527317666180207165238

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TNF-α Polymorphisms and Maternal Depression in a Mexican Mestizo Population.

CNS & neurological disorders drug targets - 26 Apr 2018

Sandoval-Carrillo Ada, Alvarado-Esquivel Cosme, Salas-Martinez Carlos, Mendez-Hernandez Edna M, Sifuentes-Alvarez Antonio, Martínez-Martinez Ana L, Castillo-Orona Juan M, Hernandez-Tinoco Jesus, Antuna-Salcido Elizabeth I, Sanchez-Anguiano Luis F, Velez Velez Lilia M, Salas-Pacheco Sergio M, Castellanos-Juarez Francisco X, Llave-Leon Osmel La, Arias-Carrion Oscar, Salas-Pacheco Jose M

Abstract excerpt

BACKGROUND: Depressive disorders are common during pregnancy. There is compelling evidence that the inflammatory response system is important in the pathophysiology of depression. Higher concentrations of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-α) in depressed subjects have been described. Because several polymorphisms in the TNF-α promoter region are known to affect its gene...

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PMID: 29424322
DOI: 10.2174/1871527317666180207165238

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