Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics.

doi:10.1038/s41431-017-0089-8

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Article

Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics.

European journal of human genetics : EJHG - 1 May 2018

Nedeljkovic Ivana, Carnero-Montoro Elena, Lahousse Lies, van der Plaat Diana A, de Jong Kim, Vonk Judith M, van Diemen Cleo C, Faiz Alen, van den Berge Maarten, Obeidat Ma'en, Bossé Yohan, Nickle David C, Consortium Bios, Uitterlinden Andre G, van Meurs Joyce J B, Stricker Bruno C H, Brusselle Guy G, Postma Dirkje S, Boezen H Marike, van Duijn Cornelia M, Amin Najaf

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a major health burden in adults and cigarette smoking is considered the most important environmental risk factor of COPD. Chromosome 15q25.1 locus is associated with both COPD and smoking. Our study aims at understanding the mechanism underlying the association of chromosome 15q25.1 with COPD through epigenetic and transcriptional variation in a population-based...

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Share to Chromosomes, Human, Pair 15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proteasome Endopeptidase Complex

Share to Pulmonary Disease, Chronic Obstructive

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Source

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Identifiers

PMID: 29422661
DOI: 10.1038/s41431-017-0089-8
PMCID: PMC5945654

Genes

CHRNA3
PSMA4
HYKK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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