Article
Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Molecular pharmaceutics - 5 Mar 2018
Juvonen Risto O, Rauhamäki Sanna, Kortet Sami, Niinivehmas Sanna, Troberg Johanna, Petsalo Aleksanteri, Huuskonen Juhani, Raunio Hannu, Finel Moshe, Pentikäinen Olli T
Abstract excerpt
Intestinal and hepatic glucuronidation by the UDP-glucuronosyltransferases (UGTs) greatly affect the bioavailability of phenolic compounds. UGT1A10 catalyzes glucuronidation reactions in the intestine, but not in the liver. Here, our aim was to develop selective, fluorescent substrates to easily elucidate UGT1A10 function. To this end, homology models were constructed and used to design new substrates, and...
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