Article
A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh.
Cancer - 1 Jul 2015
Seow Wei Jie, Pan Wen-Chi, Kile Molly L, Tong Lin, Baccarelli Andrea A, Quamruzzaman Quazi, Rahman Mahmuder, Mostofa Golam, Rakibuz-Zaman Muhammad, Kibriya Muhammad, Ahsan Habibul, Lin Xihong, Christiani David C
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNPs) in inflammation, one-carbon metabolism, and skin cancer genes might influence susceptibility to arsenic-induced skin lesions. METHODS: A case-control study was conducted in Pabna, Bangladesh (2001-2003), and the drinking-water arsenic concentration was measured for each participant. A panel of 25 candidate SNPs was analyzed in 540 cases and 400 controls. Logistic...
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