Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung.

doi:10.1016/s0169-5002(00)00232-4

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Article

Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2001

Malkinson A M

Abstract excerpt

Primary lung tumors in mice have morphologic, histogenic, and molecular features similar to human lung adenocarcinoma, and in particular, the bronchiolo-alveolar carcinoma subtype. Because of this, and because of the genetic homology between man and mouse and the ease of genetic manipulations in mice, this model system is receiving intense research attention. This review is intended to be informative to clinical...

Topics

Animals
Antineoplastic Combined Chemotherapy Protocols
Chemoprevention
DNA, Neoplasm
Disease Models, Animal
Disease Progression
Genetic Predisposition to Disease
Humans
Lung Neoplasms
Mice
Transplantation, Heterologous

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Open in PubMed

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PMID: 11390008
DOI: 10.1016/s0169-5002(00)00232-4

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