Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

1 Feb 2018

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder of which the progression is influenced by several disease-modifying factors. Here, we investigated ELP3, a subunit of the elongator complex that modifies tRNA wobble uridines, as one of such ALS disease modifiers. ELP3 attenuated the axonopathy of a mutant SOD1, as well as of a mutant C9orf72 ALS zebrafish model. Furthermore, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29415125
DOI: 10.1093/hmg/ddy043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elongator subunit 3 (ELP3) modifies ALS through tRNA modificationPMID 29415125Read ↗

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.Semantic proximity Read ↗

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis in Alzheimer’s disease modelsSemantic proximity Read ↗

tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memorySemantic proximity Read ↗

EXOSC10-mediated pre-tRNA surveillance safeguards neuron survivalSemantic proximity Read ↗

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior.Semantic proximity Read ↗

Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants.Semantic proximity Read ↗

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicitySemantic proximity Read ↗

Expression of amyotrophic lateral sclerosis associated protein disulfide isomerase A3 D217N variant recapitulates early morphological alterations at the neuromuscular junction.Semantic proximity Read ↗

Nuclear depletion of RNA binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosisSemantic proximity Read ↗

Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosisSemantic proximity Read ↗

3’UTR variants of ALS-linked RNAs modify subcellular and cellular phenotypesSemantic proximity Read ↗

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.