Genetic Determinants of Japanese Encephalitis Virus Vaccine Strain SA14-14-2 That Govern Attenuation of Virulence in Mice.

doi:10.1128/JVI.00219-15

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genetic Determinants of Japanese Encephalitis Virus Vaccine Strain SA14-14-2 That Govern Attenuation of Virulence in Mice.

Journal of virology - 1 Jun 2015

Gromowski Gregory D, Firestone Cai-Yen, Whitehead Stephen S

Abstract excerpt

UNLABELLED: The safety and efficacy of the live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine are attributed to mutations that accumulated in the viral genome during its derivation. However, little is known about the contribution that is made by most of these mutations to virulence attenuation and vaccine immunogenicity. Here, we generated recombinant JEV (rJEV) strains containing JEV SA14-14-2...

Topics

Aedes
Amino Acid Substitution
Animals
Cell Line
Chlorocebus aethiops
Disease Models, Animal
Encephalitis Virus, Japanese
Encephalitis, Viral
Female
Genes, Viral
Humans
Japanese Encephalitis Vaccines
Mice
Mutation
Vaccines, Attenuated
Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 25855730
DOI: 10.1128/JVI.00219-15
PMCID: PMC4474313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics