Article
Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease.
Nature neuroscience - 1 Feb 2014
Xiong Wei, Chen Shao-Rui, He Liming, Cheng Kejun, Zhao Yi-Lin, Chen Hong, Li De-Pei, Homanics Gregg E, Peever John, Rice Kenner C, Wu Ling-gang, Pan Hui-Lin, Zhang Li
Abstract excerpt
Although postsynaptic glycine receptors (GlyRs) as αβ heteromers attract considerable research attention, little is known about the role of presynaptic GlyRs, likely α homomers, in diseases. Here, we demonstrate that dehydroxylcannabidiol (DH-CBD), a nonpsychoactive cannabinoid, can rescue GlyR functional deficiency and exaggerated acoustic and tactile startle responses in mice bearing point mutations in α1 GlyRs...
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