Article
Lack of positive allosteric modulation of mutated alpha(1)S267I glycine receptors by cannabinoids.
Naunyn-Schmiedeberg's archives of pharmacology - 1 May 2010
Foadi Nilufar, Leuwer Martin, Demir Reyhan, Dengler Reinhard, Buchholz Vanessa, de la Roche Jeanne, Karst Matthias, Haeseler Gertrud, Ahrens Jörg
Abstract excerpt
Loss of inhibitory synaptic transmission within the dorsal horn of the spinal cord plays a key role in the development of chronic pain following inflammation or nerve injury. Inhibitory postsynaptic transmission in the adult spinal cord involves mainly glycine. Ajulemic acid and HU210 are non-psychotropic, synthetic cannabinoids. Cannabidiol is a non-psychotropic plant constituent of cannabis sativa. There are...
Topics
- Allosteric Regulation
- Amino Acid Sequence
- Cannabidiol
- Cell Line
- Dronabinol
- Humans
- Mutation
- Patch-Clamp Techniques
- Receptors, Glycine