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Article

Lovastatin promotes myelin formation in NPC1 mutant oligodendrocytes.

Journal of the neurological sciences - 15 Mar 2018

Yang Fan, Feng Xiao, Rolfs Arndt, Luo Jiankai

Abstract excerpt

Niemann-Pick Type C (NPC) disease is a rare neurovisceral disorder caused by mutations of either NPC1 or NPC2 gene and characterized by defective intracellular transport of cholesterol and glycosphingolipids, leading to neuron loss and myelin aberration in the central nervous system. In this study, by comparing protein expression in the cortical white matter tracts from mice at different postnatal days, we...

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Source

Identifiers

PMID: 29406968
DOI: 10.1016/j.jns.2018.01.015

Genes

NPC1
MBP
NPC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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