Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant expressions of delta-protocadherins in the brain of Npc1 mutant mice.

Histology and histopathology - 1 Sept 2014

Yan Xin, Lukas Jan, Lin Juntang, Ernst Mathias, Koczan Dirk, Witt Martin, Fuellen Georg, Wree Andreas, Rolfs Arndt, Luo Jiankai

Abstract excerpt

Niemann-Pick type C1 (NPC1) disease is an autosomal recessive disorder characterized by dysmyelination and neurodegeneration, which can result in the death of patients in early childhood in some cases. Members of the delta-protocadherins (Pcdhs) play important roles in neurogenesis and brain deve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Cadherins
Share to In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Mice, Mutant Strains

Share to Niemann-Pick C1 Protein

Share to Niemann-Pick Disease, Type C

Share to Oligonucleotide Array Sequence Analysis

Source

Identifiers

PMID: 24671883
DOI: 10.14670/HH-29.1185

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24671883-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant expressions of delta-protocadherins in the brain of Npc1 mutant mice.PMID 24671883Read ↗

Regional and developmental expression of the Npc1 mRNA in the mouse brain.Semantic proximity Read ↗

Patterned Purkinje cell degeneration in mouse models of Niemann‐Pick type C diseaseSemantic proximity Read ↗

Lovastatin promotes myelin formation in NPC1 mutant oligodendrocytes.Semantic proximity Read ↗

Hepatic and neuronal phenotype of NPC1−/− miceSemantic proximity Read ↗

The role and expression of the protocadherin-alpha clusters in the CNS.Semantic proximity Read ↗

Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafishSemantic proximity Read ↗

A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex.Semantic proximity Read ↗

Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein.Semantic proximity Read ↗

Neurodegeneration in the olfactory system in Niemann Pick type C1 diseaseSemantic proximity Read ↗

[Activity of glial cells in the olfactory bulb of Niemann-Pick disease type C1 mice].Semantic proximity Read ↗

NPC1 Gene Deficiency Leads to Lack of Neural Stem Cell Self-Renewal and Abnormal Differentiation Through Activation of p38 Mitogen-Activated Protein Kinase SignalingSemantic proximity Read ↗

Neuronal Populations Involved in Motor Function Show Prominent Expression of Sbno1 during Postnatal Brain DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.