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Article

Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm).

Journal of the peripheral nervous system : JPNS - 1 Jun 2001

Watabe K, Ida H, Uehara K, Oyanagi K, Sakamoto T, Tanaka J, Garver W S, Miyawaki S, Ohno K, Eto Y

Abstract excerpt

Niemann-Pick disease type C (NPC) is characterized by an accumulation of unesterified cholesterol in the endosomal/lysosomal (E/L) system, resulting in progressive neurodegeneration and death during early childhood. To investigate the cellular pathomechanism of nervous system involvement in NPC, continuous neural cell lines are desirable. In this study, we obtained neuronal and Schwann cell cultures and...

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Source

Identifiers

PMID: 11446388
DOI: 10.1046/j.1529-8027.2001.01012.x

Genes

NPC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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