Article
Lack of association between IL-1β, TNF-α, and IL-10 gene polymorphisms and sporadic Parkinson's disease in an Italian cohort.
Acta neurologica Scandinavica - 1 Sept 2011
Pascale E, Passarelli E, Purcaro C, Vestri A R, Fakeri A, Guglielmi R, Passarelli F, Meco G
Abstract excerpt
OBJECTIVE: There is increasing evidence suggesting that neuroinflammation and microglia activation may play important roles in the pathway leading to neuronal cell death in Parkinson's disease (PD). Chronic activation of microglia may cause neuronal damage through the release of potentially cytotoxic molecules, such as pro-inflammatory cytokines. Different functional promoter polymorphisms within genes coding...
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