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Interleukin-18 promoter polymorphisms and risk of Parkinson's disease in a Han Chinese population.

Brain research - 24 Mar 2011

Xu Xiang, Li Dequan, He Qing, Gao Jing, Chen Biao, Xie Anmu

Abstract excerpt

The etiology of sporadic Parkinson's disease (PD) is not well established. Interleukin-18 (IL-18), a member of pro-inflammatory cytokines, might influence the risk of sporadic PD occurrence and development. In this study, two DNA polymorphisms at interleukin (IL)-18 promoter, -607C/A (rs1946518) and -137G/C (rs187238), were examined in sporadic PD patients in a Han Chinese population with 290 sporadic PD patients...

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PMID: 21241672
DOI: 10.1016/j.brainres.2011.01.025

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