Article
Targeted metabolomics suggests a probable role of the FTO gene in the kynurenine pathway in prediabetes.
PeerJ - 1 Jan 2022
Chailurkit La-Or, Chanprasertyothin Suwannee, Thongmung Nisakron, Sritara Piyamitr, Ongphiphadhanakul Boonsong
Abstract excerpt
Background: Genome-wide association studies have identified the alpha-ketoglutarate dependent dioxygenase gene (FTO) as the first susceptibility gene of obesity. In the present study, we utilized targeted metabolomics in an attempt to further elucidate mechanisms underlying the action of the FTO gene. Methods: This study was part of a health survey of employees of the Electricity Generating Authority of Thailand...
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