Article
ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer.
Scientific reports - 5 Feb 2018
Pellinen Teijo, Blom Sami, Sánchez Sara, Välimäki Katja, Mpindi John-Patrick, Azegrouz Hind, Strippoli Raffaele, Nieto Raquel, Vitón Mariano, Palacios Irene, Turkki Riku, Wang Yinhai, Sánchez-Alvarez Miguel, Nordling Stig, Bützow Anna, Mirtti Tuomas, Rannikko Antti, Montoya María C, Kallioniemi Olli, Del Pozo Miguel A
Abstract excerpt
Caveolin-1 (CAV1) is over-expressed in prostate cancer (PCa) and is associated with adverse prognosis, but the molecular mechanisms linking CAV1 expression to disease progression are poorly understood. Extensive gene expression correlation analysis, quantitative multiplex imaging of clinical samples, and analysis of the CAV1-dependent transcriptome, supported that CAV1 re-programmes TGFβ signalling from tumour...
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