Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caveolin-1 is up-regulated by GLI1 and contributes to GLI1-driven EMT in hepatocellular carcinoma.

PloS one - 1 Jan 2014

Gai Xiaohong, Lu Zhongtang, Tu Kangsheng, Liang Zheyong, Zheng Xin

Abstract excerpt

Caveolin-1 (Cav-1) has been recently identified to be over-expressed in hepatocellular carcinoma (HCC) and promote HCC cell motility and invasion ability via inducing epithelial-mesenchymal transition (EMT). However, the mechanism of aberrant overexpression of Cav-1 remains vague. Here, we observed that Cav-1 expression was positively associated with GLI1 expression in HCC tissues. Forced expression of GLI1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Caveolin 1
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Mice, Nude

Share to Neoplasm Invasiveness

Share to Xenograft Model Antitumor Assays

Share to Zinc Finger Protein GLI1

Source

Open in PubMed Open full text

Identifiers

PMID: 24454730
DOI: 10.1371/journal.pone.0084551
PMCID: PMC3890273

Genes

GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caveolin-1 is up-regulated by GLI1 and contributes to GLI1-driven EMT in hepatocellular carcinoma.PMID 24454730Read ↗

The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.Semantic proximity Read ↗

Reciprocal Activating Crosstalk between c-Met and Caveolin 1 Promotes Invasive Phenotype in Hepatocellular CarcinomaSemantic proximity Read ↗

Integrated profiling identifies caveolae‐associated protein 1 as a prognostic biomarker of malignancy in glioblastoma patientsSemantic proximity Read ↗

Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway.Semantic proximity Read ↗

Genetic variations of CAV1 gene contribute to HCC risk: a case-control study.Semantic proximity Read ↗

The contribution of caveolin-1 genotype and phenotype to hepatocellular carcinoma.Semantic proximity Read ↗

Involvement of the TGFβ pathway in the regulation of α<sub>5</sub>β<sub>1</sub> integrins by caveolin‐1 in human glioblastomaSemantic proximity Read ↗

Caveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancer.Semantic proximity Read ↗

ZEB1 promotes tumorigenesis and metastasis in hepatocellular carcinoma by regulating the expression of vimentinSemantic proximity Read ↗

ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer.Semantic proximity Read ↗

Caveolin‐1 is an Important Factor for the Metastasis and Proliferation of Human Small Cell Lung Cancer NCI‐H446 CellSemantic proximity Read ↗

A Homeobox Protein, Prox1, Is Involved in the Differentiation, Proliferation, and Prognosis in Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.